The first industrial plant to produce thiophene in the world the gas phase catalytic process of butane and sulfur (Nobiloil method, soccong-vaccum Company development), the yield is 40%, this method was patented in 1950, the 60 ‘s due to low yield, serious equipment corrosion, environmental pollution and shutdown. The newer methods are: ① gas-phase catalysis, the presence of thiophene, Butadiene, N-butanol, butene and carbon or sulphur dioxide in alkali-catalyzed metal oxide catalysts in 500 ℃ reactions, and the derivatives of the compounds were obtained. ② by furan or methyl furan and carbon in Zaduo acid catalysis at 400 ℃ reaction, The preparation of thiophene and methyl thiophene, the yield is up to 93%, the catalyst life is long, does not need the cycle to regenerate, is a promising synthesis craft, the ③ butane and the sulfur gas phase mix, in 600 ℃ quick reaction; ④ in the presence of iron oxide, acetylene is heated to 300 ℃ pyrite reaction; ⑤ anhydrous sodium succinate reacts with two phosphorus sulfide in high temperature and carbon dioxide flow.

Industrially, thiophene is made from butane and sulfur, and butane is first dehydrogenation, then guan with sulfur to form thiophene. In the laboratory, Thiophene was made from 1, 4-two carbonyl compounds and three sulfide two phosphorus reactions. Acetyl Butanone reacts with parathion to produce 2, 5-two methyl thiophene.